Role Of Cytokines In The Body

The most important factors in the regulation of humoral immunity are cytokines (CC): interleukin (IL) -1, IL-6, tumor necrosis factor (TNF)-, which plays the role of proinflammatory factors, and IL-4, effects which are seen as antagonistic. The aim of the study was to investigate IL-1, 4, 6, and TNF- in the serum of mature male albino rats in the dynamics of cb. Conducted two series of experiments: control and simulation of cb stimulation by electrocutaneous receptor area of the tail within 60 days. Fence of biological material for research was carried out on the cc 1,5,15,30,60 day of hb syndrome. Concentration of cc in the serum of rats were measured by enzyme immunoassay. In Control of serum content of IL-1 was – 3,5 0,3 pg / ml IL-4 2,5 0,37 pg / ml IL-6 – 38,4 4,1 pg / ml; tnf – 17,3 2,5 pg / ml. At day 1 indicated: increase the percentage of IL-6 by 19%, IL-4 on 3% and the IL-1 decreased from 6% to 3%, TNF- decreased from 28% to 9%.

On day 5 the formation of hbs there was an increase of IL-6 from 81% to 87%, but decrease: IL-4 and TNF- by 3%. At the 15 th day of the fraction of IL-6, increased to 90% in the other faction – the tendency to decrease. At 30-s knocking was a decrease of IL-6 up to 77%, an increase of TNF- to 13% increase fractions of IL-1 and IL-4. On 60 th day of hbs decrease in the proportion of IL-6 by 19%, an increase of IL-1 at 4%, IL-4 and TNF- by 7%. In general, the overall thrust of the cytokine activity in the dynamics of the hbs is presented entirely rational form of response, characterizing it Phase changes of the primary pronounced increase in the level of both pro-and anti-inflammatory cytokines at lower concentrations of tnf, a further progressive increase of pro-inflammatory component and a weakening anti-inflammatory effects in the prolongation of pain and gain of anti-inflammatory effects during the chronic process in the stabilization of high levels of IL-4 and inhibition of proinflammatory activities.